Methimazole has no dose-related effect on the intensity of the intrathyroidal autoimmune process in relapsing Graves' disease.

@article{Paschke1995MethimazoleHN,
  title={Methimazole has no dose-related effect on the intensity of the intrathyroidal autoimmune process in relapsing Graves' disease.},
  author={Ralph Paschke and M Vogg and R Kristoferitsch and D Aktuna and O. Wawschinek and Otto Eber and Klaus Henning Usadel},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1995},
  volume={80 8},
  pages={2470-4}
}
Declining thyroid autoantibodies during treatment and decreased lymphocytic infiltration after treatment of patients with Graves' disease suggest immunosuppressive actions of antithyroid drugs. However, the recent report of similar relapse rates after low and high dose carbimazole treatment of Graves' disease seems to contradict the immunosuppression thesis… CONTINUE READING