Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.

@article{Zoraghi2011MethicillinresistantSA,
  title={Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.},
  author={Roya Zoraghi and Liam Worrall and Raymond H. See and Wendy Karen Strangman and Wendy L Popplewell and Huansheng Gong and Toufiek Samaai and Richard D Swayze and Sukhbir Kaur and Marija Vuckovic and B. Brett Finlay and Robert C. Brunham and W. Robert McMaster and Michael T Davies-Coleman and Natalie C. J. Strynadka and Raymond J Andersen and Neil E. Reiner},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 52},
  pages={44716-25}
}
Novel classes of antimicrobials are needed to address the emergence of multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). We have recently identified pyruvate kinase (PK) as a potential novel drug target based upon it being an essential hub in the MRSA interactome (Cherkasov, A., Hsing, M., Zoraghi, R., Foster, L. J., See, R. H., Stoynov, N., Jiang, J., Kaur, S., Lian, T., Jackson, L., Gong, H., Swayze, R., Amandoron, E., Hormozdiari, F., Dao, P., Sahinalp… CONTINUE READING
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