Methemoglobinemia After Lidocaine Administration

  • Published 2006


However, several years ago, Hailer and Plitm measured the temperature changes during two minutes’ nebulization of histamine from a Wright nebulizer and found it to be exactly the same as in the present report. They went on to investigate whether this temperature drop may have any clinical effect and compared the response to inhaled histamine (PC20) between nebulizers operating at different but constant temperatures. The nebulizers were designed to prevent any temperature drop during nebulization, Two groups of asthmatic patients were studied: one group inhaled the aerosol at constant 30#{176}C,whereas the other inhaled the aerosol at constant 23#{176}C. In both groups the results were compared to those obtained during the usual test performed at room temperature (23#{176}C)without keeping the temperature constant. The results (PC O in mg/ml) are presented in the table, Thus, keeping the temperature constant increased PC2 (reduced airway reactivity) compared with the standard method. The higher the temperature was kept, the greater PCI, (reactivity was further reduced). Deducing from Cockroft’s study (Figure 2 and Discussion), one would assume that, compared to the usual method, keeping the temperature constant would prevent the observed reduction in nebulizer output and hence PC,,, should be smaller. The results of Hailer and Plit’s study (which showed an opposite effect) contradicted this assumption. Moreover, the fact that the effect was enhanced at higher (constant) temperatures indicate a significant role for temperature in the results. Indeed, we have recently demonstrated the importance of temperature in modifing airway response even in normal subjects. In view of Haifer and Plit’s results, the report of Cockfort et al is important not only in terms of standardization and methodology but also in clinical terms.

Cite this paper

@inproceedings{2006MethemoglobinemiaAL, title={Methemoglobinemia After Lidocaine Administration}, author={}, year={2006} }