Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in PPHN

@article{Pabalan2009MethemoglobinTC,
  title={Methemoglobin to cumulative nitric oxide ratio and response to inhaled nitric oxide in PPHN},
  author={Maria Janina U Pabalan and Sandeep P Nayak and Rita M. Ryan and V. S. Harish Kumar and Satyan Lakshminrusimha},
  journal={Journal of Perinatology},
  year={2009},
  volume={29},
  pages={698-701}
}
Background:One-third of infants with persistent pulmonary hypertension of the newborn (PPHN) do not respond to inhaled nitric oxide (iNO). If iNO is not delivered to the pulmonary vasculature because of parenchymal lung disease, it cannot interact with hemoglobin to form methemoglobin (MHb).Objective:To study the correlation between oxygenation response to iNO in infants with PPHN secondary to parenchymal lung disease and initial MHb% to cumulative NO exposure (ppm × hours) ratio (MHb/ΣNO… CONTINUE READING

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