Methemoglobin—It's not just blue: A concise review

  title={Methemoglobin—It's not just blue: A concise review},
  author={J. Umbreit},
  journal={American Journal of Hematology},
  • J. Umbreit
  • Published 2007
  • Chemistry, Medicine
  • American Journal of Hematology
  • Hemoglobin has functions besides carrying oxygen to the tissues, and regulates vascular tone and inflammation via a redox couple with methemoglobin. Hemoglobin has iron in the reduced valance Fe(II) and methemoglobin has iron in the oxidized valance Fe (III), with a free energy capable of producing water from oxygen. In generating methemoglobin the couple functions as a nitrite reductase. The degree of oxidation of hemoglobin senses the oxygen level in the blood and uses its ability to produce… CONTINUE READING
    273 Citations

    Paper Mentions

    Interventional Clinical Trial
    To establish and compare maximum methemoglobin blood levels and times to maximum methemoglobin blood levels following the administration of the injectable local anesthetics… Expand
    Alternate and Additional Functions of Erythrocyte Hemoglobin
    • 6
    Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells
    • 7
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    Carbon Monoxide Promotes Respiratory Hemoproteins Iron Reduction Using Peroxides as Electron Donors
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    Heme degradation and vascular injury.
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    Acute patho-toxicological indicators of methaemoglobinemia
    • 1
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    Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO‐1 induction
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    The Role of Hemoproteins: Hemoglobin, Myoglobin and Neuroglobin in Endogenous Thiosulfate Production Processes
    • 7
    • PDF
    Towards nitrite as a therapy in cardiovascular disease
    • 1
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    Concise review: methemoglobinemia.
    • 263
    Proposed Mechanism of Nitrite-Induced Methemoglobinemia
    • 49
    The oxyhemoglobin reaction of nitric oxide.
    • 385
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    Antioxidant protein 2 prevents methemoglobin formation in erythrocyte hemolysates.
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    Nitric oxide binding to oxygenated hemoglobin under physiological conditions.
    • 91
    Different Faces of the Heme-Heme Oxygenase System in Inflammation
    • 511
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    Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL.
    • 95
    Pro-oxidant and cytotoxic effects of circulating heme.
    • 523
    • PDF
    Mechanism of low-density lipoprotein oxidation by hemoglobin-derived iron.
    • 74
    • Highly Influential
    Iron release, oxidative stress and erythrocyte ageing.
    • 183