Methanol induces a discrete transcriptional dysregulation that leads to cytokine overproduction in activated lymphocytes.

@article{Dsy2010MethanolIA,
  title={Methanol induces a discrete transcriptional dysregulation that leads to cytokine overproduction in activated lymphocytes.},
  author={Olivier D{\'e}sy and Damien Carignan and Manuel Caruso and Pedro O. de Campos-Lima},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={117 2},
  pages={
          303-13
        }
}
Methanol is an important cause of acute alcohol intoxication; it is ubiquitously present at home and in the workplace. Although the existing literature provides a reasonable insight into the immunological impact of ethanol and to a much lesser extent of isopropanol, much less data are available on methanol. We hypothesized on structural grounds that methanol would share the immunosuppressive properties of the two other short-chain alcohols. We report here that methanol increases the… 
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The dysregulation of the monocyte/macrophage effector function induced by isopropanol is mediated by the defective activation of distinct members of the AP-1 family of transcription factors.
TLDR
The results showed that Toll-like receptor 4 early signaling was preserved, as isopropanol did not change the kinase activity of the IL-1 receptor-associated kinase 1 in LPS-stimulated cells, and the nuclear factor-κB signaling cascade and the p38/c-Jun N-terminal kinase modules of the mitogen-activated protein kinase pathway were alcohol insensitive.
Mécanismes d'immunomodulation par les alcanols aliphatiques
TLDR
The results suggest the existence of interaction pockets of defined dimensions within intracellular targets that compromise the activation of the NFAT and NF-κB transcription factors and ultimately modulate the effector function of T lymphocytes.
Short-term immunological effects of non-ethanolic short-chain alcohols.
Aliphatic alcohol contaminants of illegally produced spirits inhibit phagocytosis by human granulocytes
TLDR
Due to their synergistic effects, it is possible that, in combination with ethanol, they may inhibit phagocytosis in a clinically meaningful way in episodic heavy drinkers.
Considerations regarding use of solvents in in vitro cell based assays
TLDR
The effects induced by solvents even at low concentrations are highly relevant for the interpretation of immunomodulatory effects evaluated in cell assays and show the importance of keeping solvent concentrations constant in serial dilution of any compound investigated in cell based assays.
The Size of the Unbranched Aliphatic Chain Determines the Immunomodulatory Potency of Short and Long Chain n-Alkanols*
TLDR
The pattern of immunomodulation and transcriptional dysregulation induced by the n-alkanol series suggested the existence of interaction pockets of defined dimensions within intracellular targets that compromise the activation of NFAT and NF-κB transcription factors and ultimately modulate the effector function of the T lymphocyte.
Benign Effect of Extremely Low-Frequency Electromagnetic Field on Brain Plasticity Assessed by Nitric Oxide Metabolism during Poststroke Rehabilitation
TLDR
It is concluded that ELF-EMF therapy is capable of promoting recovery in poststroke patients by significantly increased 3-nitrotyrosine and nitrate/nitrite levels and expression of NOS2 was insignificantly decreased in both groups.

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