Methanocaldococcus jannaschii Uses a Modified Mevalonate Pathway for Biosynthesis of Isopentenyl Diphosphate

@article{Grochowski2006MethanocaldococcusJU,
  title={Methanocaldococcus jannaschii Uses a Modified Mevalonate Pathway for Biosynthesis of Isopentenyl Diphosphate},
  author={Laura L. Grochowski and Huimin Xu and Robert H. White},
  journal={Journal of Bacteriology},
  year={2006},
  volume={188},
  pages={3192 - 3198}
}
ABSTRACT Archaea have been shown to produce isoprenoids from mevalonate; however, genome analysis has failed to identify several genes in the mevalonate pathway on the basis of sequence similarity. A predicted archaeal kinase, coded for by the MJ0044 gene, was associated with other mevalonate pathway genes in the archaea and was predicted to be the “missing” phosphomevalonate kinase. The MJ0044-derived protein was tested for phosphomevalonate kinase activity and was found not to catalyze this… 
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TLDR
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