Methamphetamine-like discriminative-stimulus effects of nicotinic agonists.

  title={Methamphetamine-like discriminative-stimulus effects of nicotinic agonists.},
  author={Rajeev I. Desai and J. R. Bergman},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={348 3},
Nicotine was recently shown to engender d-methamphetamine (MA)-like discriminative-stimulus effects in rats, which may be indicative of shared psychomotor stimulant properties. To further investigate such overlapping discriminative-stimulus effects, nicotinic agonists varying in efficacy and selectivity were studied in squirrel monkeys that discriminated a moderate intramuscular dose of MA (0.1 mg/kg) from vehicle. These included α4β2-selective ligands that may vary in efficacy from relatively… CONTINUE READING
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