Methamphetamine induces DNA damage in specific regions of the female rat brain

  title={Methamphetamine induces DNA damage in specific regions of the female rat brain},
  author={Zane Johnson and Jace Venters and Fay A. Guarraci and Maha Zewail-Foote},
  journal={Clinical and Experimental Pharmacology and Physiology},
Methamphetamine (METH) is a highly addictive psychostimulant that has been shown to produce neurotoxicity. Methamphetamine increases the release of dopamine by reversing the direction of monoamine transporter proteins, leading to the formation of reactive oxygen species in the brain. In this study, we examined the effect of METH on DNA damage in vivo using the single cell gel electrophoresis assay (comet assay) under two different conditions. Rats treated with multiple doses of METH (10 mg/kg… 

Methamphetamine ("crystal meth") causes induction of DNA damage and chromosomal aberrations in human derived cells.

  • Nathalie RopekHalh Al-Serori F. Ferk
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2019

Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain

The results suggest that LINE-1 activation might occur in neurogenic areas in human METH users and might contribute to METH abuse-induced hippocampus-dependent memory deficits and impaired performance on several cognitive tasks mediated by the striatum.

Epigallocatechin Gallate Mitigates the Methamphetamine-Induced Striatal Dopamine Terminal Toxicity by Preventing Oxidative Stress in the Mouse Brain

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The Role of Oxidative Stress in Methamphetamine-induced Toxicity and Sources of Variation in the Design of Animal Studies

The development of guidelines and how best to assess oxidative stress in animal models may be beneficial and the use of these simple recommendations mean that results will be more comparable between laboratories and that future results generated will give a greater understanding of the contribution of this important biochemical mechanism.

Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats

The induction of head-twitch response and potentiation of forepaw treading induced by 8-OH-DPAT indicate that hallucinogenic activity seems to be mediated through the stimulation of 5-HT2A and5-HT1A receptors by 5-MeO-DIPT.

Increased blood 8-hydroxy-2-deoxyguanosine levels in methamphetamine users during early abstinence

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Sulforaphane alleviates methamphetamine-induced oxidative damage and apoptosis via the Nrf2-mediated pathway in vitro and in vivo

Results indicate that SFN might be a promising functional food-derived compound for preventing METH-induced neurotoxicity via the Nrf2-mediated pathway.

Novel Psychoactive Phenethylamines: Impact on Genetic Material

The results highlight the importance of genotoxicity evaluation for a complete assessment of the risk associated also with NPS exposure and show a statistically significant increase in ROS levels for all genotoxic phenethylamines confirming this hypothesis.



Cocaine induces DNA damage in distinct brain areas of female rats under different hormonal conditions

Sexual hormones exhibited a neuroprotective effect, decreasing cocaine‐induced DNA damage in cycling rats in all brain areas, except in the hypothalamus, where repeated treatment did not cause increased DNA damage.

BRIEF REPORT: Single exposure to cocaine or ecstasy induces DNA damage in brain and other organs of mice

It is demonstrated that cocaine and MDMA are potent genotoxins and all doses tested were able to induce DNA damage in blood cells.

Speed kills: cellular and molecular bases of methamphetamine‐induced nerve terminal degeneration and neuronal apoptosis

Data suggesting the participation of endoplasmic reticulum and mitochondria‐mediated activation of caspase‐dependent and ‐independent cascades in the manifestation of METH‐induced apoptosis is discussed.

Intrastriatal injection of dopamine results in DNA damage and apoptosis in rats

Demonstration of DA-induced apoptosis in vivo may provide a potential molecular mechanism for DA neurotoxicity, which is implicated in the neurodegenerative processes in ischemia, hypoxia and local exposure to high concentrations of excitatory amino acids.

Rapid Communication: Attenuation of Methamphetamine‐Induced Neurotoxicity in Copper/Zinc Superoxide Dismutase Transgenic Mice

The results suggest that METH‐induced dopaminergic toxicity in mice may be secondary to increased production of reactive oxygen species such as the superoxide radical.

Dopamine Quinone Formation and Protein Modification Associated with the Striatal Neurotoxicity of Methamphetamine: Evidence against a Role for Extracellular Dopamine

It is likely that dopamine oxidation contributes to methamphetamine-induced toxicity to dopamine terminals, adding support to the role of dopamine and the evidence of oxidative stress in this lesion model.

The effects of methamphetamine on the production of free radicals and oxidative stress.

  • B. YamamotoW. Zhu
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1998
The results illustrate that METH increases pro-oxidant processes and offer supportive evidence that Meth produces oxidative damage and demonstrate that iron may be involved in mediating the long-term damage to dopamine neurons after repeated administrations of METH.