Methamphetamine-induced sensitization differentially alters pCREB and DeltaFosB throughout the limbic circuit of the mammalian brain.

@article{McDaid2006MethamphetamineinducedSD,
  title={Methamphetamine-induced sensitization differentially alters pCREB and DeltaFosB throughout the limbic circuit of the mammalian brain.},
  author={John McDaid and Martin P Graham and T. Celeste Napier},
  journal={Molecular pharmacology},
  year={2006},
  volume={70 6},
  pages={2064-74}
}
Enhancements in behavior that accompany repeated, intermittent administration of abused drugs (sensitization) endure long after drug administration has ceased. Such persistence reflects changes in intracellular signaling cascades and associated gene transcription factors in brain regions that are engaged by abused drugs. This process is not characterized… CONTINUE READING