Methamphetamine-induced rapid and reversible reduction in the activities of tryptophan hydroxylase and dopamine transporters: oxidative consequences?

@article{Hanson1998MethamphetamineinducedRA,
  title={Methamphetamine-induced rapid and reversible reduction in the activities of tryptophan hydroxylase and dopamine transporters: oxidative consequences?},
  author={Glen R. Hanson and James W. Gibb and Ryan Metzger and Jerry M Kokoshka and Annette Elizabeth Fleckenstein},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={844},
  pages={
          103-7
        }
}
Treatment with high doses of methamphetamine (METH) results in dramatic changes in extrapyramidal monoaminergic systems. Elevated concentrations of extracellular dopamine (DA), caused by METH administration, are thought to contribute to these effects due to the oxidative potential of this reactive catecholamine. According to this hypothesis monoaminergic cellular elements, which are vulnerable to oxidative modification, may be especially sensitive to high-dose METH treatments. We confirmed this… CONTINUE READING

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