Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain.

@article{Gonalves2008MethamphetamineinducedEI,
  title={Methamphetamine-induced early increase of IL-6 and TNF-alpha mRNA expression in the mouse brain.},
  author={Joana Gonçalves and T{\^a}nia Martins and Raquel L. Ferreira and Nuno Milhazes and Fernanda Borges and Carlos Alberto Fontes Ribeiro and Jo{\~a}o Oliveira Malva and Tice R. A. Macedo and Ana Paula Silva},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1139},
  pages={103-11}
}
The mechanisms by which methamphetamine (METH) causes neurotoxicity are not well understood. Recent studies have suggested that METH-induced neuropathology may result from a multicellular response in which glial cells play a prominent role, and so it is plausible to suggest that cytokines may participate in the toxic effects of METH. Therefore, in the present work we evaluated the effect of an acute administration of METH (30 mg/kg in a single intraperitoneal injection) on the interleukin (IL… CONTINUE READING
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