Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells.

@article{Ramirez2009MethamphetamineDB,
  title={Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells.},
  author={Servio H. Ramirez and Raghava Potula and Shongshan Fan and Tess M Eidem and Anil Papugani and Nancy L. Reichenbach and Holly Dykstra and Babette Weksler and Ignacio Andres Romero and Pierre Olivier Couraud and Yuri Persidsky},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2009},
  volume={29 12},
  pages={1933-45}
}
Methamphetamine (METH), a potent stimulant with strong euphoric properties, has a high abuse liability and long-lasting neurotoxic effects. Recent studies in animal models have indicated that METH can induce impairment of the blood-brain barrier (BBB), thus suggesting that some of the neurotoxic effects resulting from METH abuse could be the outcome of barrier disruption. In this study, we provide evidence that METH alters BBB function through direct effects on endothelial cells and explore… CONTINUE READING
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