Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction.

  title={Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction.},
  author={Lewis S. Seiden and Karen E Sabol},
  journal={NIDA research monograph},
Methamphetamine and MDMA as well as similar substituted phenethylamines are toxic to DA and/or 5-HT neurons. The duration and magnitude of these effects are dose dependent and are accompanied by different degrees of recovery. MDMA-induced 5-HT damage persists for up to 52 weeks in the rat, and methamphetamine-induced DA damage persists for up to 3 years in the rhesus monkey. Several possible mechanisms of amphetamine-analog toxicity have been reviewed. The excitatory feed-forward loop theory is… 

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  • 1987
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