Methamphetamine Self-Administration in Mice Decreases GIRK Channel-Mediated Currents in Midbrain Dopamine Neurons

@inproceedings{Sharpe2014MethamphetamineSI,
  title={Methamphetamine Self-Administration in Mice Decreases GIRK Channel-Mediated Currents in Midbrain Dopamine Neurons},
  author={Amanda L Sharpe and Erika Varela and Lynne N. Bettinger and Michael J Beckstead},
  booktitle={The international journal of neuropsychopharmacology},
  year={2014}
}
BACKGROUND Methamphetamine is a psychomotor stimulant with abuse liability and a substrate for catecholamine uptake transporters. Acute methamphetamine elevates extracellular dopamine, which in the midbrain can activate D2 autoreceptors to increase a G-protein gated inwardly rectifying potassium (GIRK) conductance that inhibits dopamine neuron firing. These studies examined the neurophysiological consequences of methamphetamine self-administration on GIRK channel-mediated currents in… CONTINUE READING
Highly Cited
This paper has 115 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

5 Figures & Tables

Topics

Statistics

0501002015201620172018
Citations per Year

115 Citations

Semantic Scholar estimates that this publication has 115 citations based on the available data.

See our FAQ for additional information.