Methamphetamine Administration Targets Multiple Immune Subsets and Induces Phenotypic Alterations Suggestive of Immunosuppression

@inproceedings{Harms2012MethamphetamineAT,
  title={Methamphetamine Administration Targets Multiple Immune Subsets and Induces Phenotypic Alterations Suggestive of Immunosuppression},
  author={Robert Harms and Brenda M. Morsey and Craig W. Boyer and Howard S. Fox and Nora E. Sarvetnick},
  booktitle={PloS one},
  year={2012}
}
Methamphetamine (Meth) is a widely abused stimulant and its users are at increased risk for multiple infectious diseases. To determine the impact of meth on the immune system, we utilized a murine model that simulates the process of meth consumption in a typical addict. Our phenotypic analysis of leukocytes from this dose escalation model revealed that meth affected key immune subsets. Meth administration led to a decrease in abundance of natural killer (NK) cells and the remaining NK cells… CONTINUE READING