Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly

  title={Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly},
  author={K K Szumlinski and Kevin D. Lominac and Rianne R. Campbell and Matan Cohen and Tod E. Kippin},
  journal={Biological Psychiatry},
BACKGROUND The high prevalence and severity of methamphetamine (MA) abuse demands greater neurobiological understanding of its etiology. METHODS We conducted immunoblotting and in vivo microdialysis procedures in MA high/low drinking mice, as well as in isogenic C57BL/6J mice that varied in their MA preference/taking, to examine the glutamate underpinnings of MA abuse vulnerability. Neuropharmacological and Homer2 knockdown approaches were also used in C57BL/6J mice to confirm the role for… CONTINUE READING
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