Methadone metabolism by human placenta.

  title={Methadone metabolism by human placenta.},
  author={Tatiana N. Nanovskaya and Sujal V. Deshmukh and Ilona A Nekhayeva and Olga L Zharikova and Gary D. V. Hankins and Mahmoud S. Ahmed},
  journal={Biochemical pharmacology},
  volume={68 3},
Methadone pharmacotherapy is considered the standard for treatment of the pregnant heroin/opioid addict. One of the factors affecting the transfer kinetics of opioids across human placenta and their levels in the fetal circulation is their metabolism by the tissue. The aim of this investigation is to identify the enzyme(s) responsible for the metabolism of methadone, determine the kinetics of the reaction and the metabolites formed utilizing placental tissue obtained from term healthy… CONTINUE READING

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