Methadone maintenance treatment and St. John's Wort - a case report.

@article{EichHchli2003MethadoneMT,
  title={Methadone maintenance treatment and St. John's Wort - a case report.},
  author={Dominique Eich-H{\"o}chli and Robert A. Oppliger and Kerry Powell Golay and P. Baumann and Chin B. Eap},
  journal={Pharmacopsychiatry},
  year={2003},
  volume={36 1},
  pages={
          35-7
        }
}
St. John's wort, a popular over-the-counter drug for treatment of depression, might reduce concentrations of drugs such as cyclosporin and indinavir and lead to drug resistance and treatment failure. No studies as yet have examined its influence on methadone plasma levels. The trough methadone plasma levels were measured in four patients (2 males, median age: 31 years; range 19 - 40 years) in methadone maintenance treatment just before the introduction of St. John's wort (900 mg/d) and after a… CONTINUE READING

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