Corpus ID: 10030774

Methadone maintenance treatment (MMT): a review of historical and clinical issues.

@article{Joseph2000MethadoneMT,
  title={Methadone maintenance treatment (MMT): a review of historical and clinical issues.},
  author={Herman Joseph and Sharon Stancliff and John Langrod},
  journal={The Mount Sinai journal of medicine, New York},
  year={2000},
  volume={67 5-6},
  pages={
          347-64
        }
}
Methadone maintenance has been evaluated since its development in 1964 as a medical response to the post-World War II heroin epidemic in New York City. The findings of major early studies have been consistent. Methadone maintenance reduces and/or eliminates the use of heroin, reduces the death rates and criminality associated with heroin use, and allows patients to improve their health and social productivity. In addition, enrollment in methadone maintenance has the potential toreduce the… Expand
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The majority of research suggests that MMT is associated with impaired cognitive function and that deficits extended across a range of domains, however, caution is required when interpreting these results due to the methodological limitations associated with many studies. Expand
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The impact of the rapid expansion in treatment availability in Ontario on the long-standing MMT program of the Centre for Addiction and Mental Health (CAMH) is described, suggesting access for a group of higher functioning opioid dependent patients who were previously being deterred from treatment entry by the large waiting lists and the need for priority access for pregnant and HIV positive heroin users. Expand
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References

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Implications of methadone maintenance for theories of narcotic addiction.
TLDR
The treatment, therefore, is corrective but not curative for severely addicted persons, and methadone maintenance provides a safe and effective way to normalize the function of otherwise intractable narcotic addicts. Expand
Methadone treatment protects against HIV infection: two decades of experience in the Bronx, New York City.
TLDR
Properly dosed, long-term methadone treatment was found to be a central protective factor in preventing HIV infection from the earliest days of the HIV epidemic in New York City. Expand
A controlled trial comparing buprenorphine and methadone maintenance in opioid dependence.
TLDR
Buprenorphine maintenance at 8 mg/d appears to be less than optimally efficacious under the conditions of the present study, and continued research is needed to reconcile these findings with the more positive results reported by other investigative groups. Expand
Ineffective use of psychoactive drugs. Methadone treatment is no exception.
TLDR
A consensus was reached that the dose of methadone should be individualized for each patient and that, for the majority, the most effective dose is between 50 and 100 mg. Expand
Cocaine abuse sharply reduced in an effective methadone maintenance program.
TLDR
With effective methadone maintenance using adequate dosages, the majority of patients remain in treatment and reduce cocaine abuse as well as illicit opioid use, with implications for public health by reducing the spread of infectious diseases including hepatitis B, C, D and human immunodeficiency virus (HIV-1). Expand
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In studies of patients having maintenance treatment for heroin addiction (stabilized with methadone hydrochloride in high doses of 80 to 120 mg daily), we found minimal side effects and no toxicExpand
Methadone medical maintenance (MMM): treating chronic opioid dependence in private medical practice--a summary report (1983-1998).
TLDR
The results can serve as a model for the expansion of office-based MMM treatment and educate other physicians who treat the patient about methadone maintenance and its applicability to the patient. Expand
When "enough" is not enough: new perspectives on optimal methadone maintenance dose.
TLDR
New research suggests that doses ranging from 120mg/d to more than 700 mg/d, with correspondingly higher SMLs, may be optimal for many patients, and there does not appear to be a maximum daily dose limit when determining what is adequately "enough" methadone in MMT. Expand
Buprenorphine vs methadone maintenance treatment for concurrent opioid dependence and cocaine abuse.
TLDR
The results support the superiority of higher daily buprenorphine and methadone maintenance doses vs lower doses for reducing illicit opioid use, but the results do not support the superior of bupenorphine compared with methamphetamineadone for reducing cocaine use. Expand
LONG‐TERM OUTCOME OF PATIENTS TREATED WITH METHADONE MAINTENANCE *
TLDR
The present study summarizes some statistics that seem relevant to addiction that have been admitted to methadone maintenance programs in New York since the modality was formally defined in 1%5. Expand
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