Methadone conversion to EDDP during GC-MS analysis of urine samples.

@article{Galloway1999MethadoneCT,
  title={Methadone conversion to EDDP during GC-MS analysis of urine samples.},
  author={F R Galloway and N F Bellet},
  journal={Journal of analytical toxicology},
  year={1999},
  volume={23 7},
  pages={615-9}
}
During validation of a gas chromatography-mass spectrometry (GC-MS) method for the methadone metabolite 2-ethylidine-1,5dimethyl-3,3-diphenylpyrrolidine (EDDP), it was noted that detectable levels of EDDP were found during analysis of extracts from drug-free urine samples spiked with methadone. Different amounts of EDDP were detected by GC-MS during… CONTINUE READING