Methadone: a substrate and mechanism-based inhibitor of CYP19 (aromatase).

Abstract

The peripheral conversion of testosterone to estradiol by aromatase is the primary source of endogenous estrogen in postmenopausal women. Studies indicating that placental aromatase is able to metabolize methadone to its primary metabolite, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidin (EDDP), led us to test the hypothesis that methadone is able to act… (More)
DOI: 10.1124/dmd.110.032474

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