Methacholine-induced bronchoconstriction in rats: effects of intravenous vs. aerosol delivery.

@article{Petk1997MethacholineinducedBI,
  title={Methacholine-induced bronchoconstriction in rats: effects of intravenous vs. aerosol delivery.},
  author={Ferenc Pet{\'a}k and Zolt{\'a}n Hantos and Agnes Adamicza and Tibor Asztalos and Peter D. Sly},
  journal={Journal of applied physiology},
  year={1997},
  volume={82 5},
  pages={1479-87}
}
To determine the predominant site of action of methacholine (MCh) on lung mechanics, two groups of open-chest Sprague-Dawley rats were studied. Five rats were measured during intravenous infusion of MCh (i.v. group), with doubling of concentrations from 1 to 16 micrograms.kg-1.min-1. Seven rats were measured after aerosol administration of MCh with doses doubled from 1 to 16 mg/ml (ae group). Pulmonary input impedance (ZL) between 0.5 and 21 Hz was determined by using a wave-tube technique. A… CONTINUE READING

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