MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays

Abstract

DNA methylation is a key mechanism of epigenetic regulation that is frequently altered in diseases such as cancer. To confirm the biological or clinical relevance of such changes, gene-specific DNA methylation changes need to be validated in multiple samples. We have developed the MethMarker http://methmarker.mpi-inf.mpg.de/ software to help design robust and cost-efficient DNA methylation assays for six widely used methods. Furthermore, MethMarker implements a bioinformatic workflow for transforming disease-specific differentially methylated genomic regions into robust clinical biomarkers.

DOI: 10.1186/gb-2009-10-10-r105

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Cite this paper

@inproceedings{Schffler2009MethMarkerUD, title={MethMarker: user-friendly design and optimization of gene-specific DNA methylation assays}, author={Peter J. Sch{\"{u}ffler and Thomas Mikeska and Andreas Waha and Thomas Lengauer and Christoph Bock}, booktitle={Genome Biology}, year={2009} }