Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta‐analysis

@article{Li2011MetforminVT,
  title={Metformin vs thiazolidinediones for treatment of clinical, hormonal and metabolic characteristics of polycystic ovary syndrome: a meta‐analysis},
  author={X-J Li and Y-X Yu and C-Q. Liu and W. S. Zhang and H-J Zhang and Bing Yan and L-Y Wang and S-Y Yang and S-h Zhang},
  journal={Clinical Endocrinology},
  year={2011},
  volume={74}
}
Objectives  Insulin‐sensitizing drugs (ISDs) have been advocated for the long‐term treatment of polycystic ovary syndrome (PCOS). It is therefore important to compare the efficacy and safety of ISDs such as metformin and thiazolidinediones (TZDs) for the treatment of this syndrome. 
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TLDR
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Although the effects of 2 types of insulin sensitizer drugs, metformin and pioglitazone, on clinical, metabolic, and endocrine characteristics of women with PCOS are compared, there is a significant amelioration of endocrine and metabolic indices with piog litazone in PCOS patients. Expand
Polycystic Ovarian Syndrome: Metformin or Thiazolidinediones for Cardiovascular Risk Reduction?
TLDR
Clinicians should systematically screen women with diabetes for PCOS and direct appropriate treatment at minimizing related risks based on evidence linking PCOS to diabetes and increased CV risks. Expand
Alternatives to Metformin for Patients with PCOS.
Compared with placebo, thiazolidinediones (TZDs) decrease systolic blood pressure and fasting blood glucose and insulin levels while improving menstrual irregularities in women with PCOS. MetforminExpand
Effects of Thiazolidinediones on Polycystic Ovary Syndrome: a Meta-analysis of Randomized Placebo-Controlled Trials
TLDR
The currently available data showed that TZD can effectively reduce insulin and fasting blood glucose levels in patients with PCOS, but TZDs may not effectively reduce the Ferriman-Gallwey score or androgen levels and may increase body weight. Expand
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