Metformin use in children with obesity and normal glucose tolerance--effects on cardiovascular markers and intrahepatic fat.

Abstract

OBJECTIVE To determine if metformin improves markers of inflammation, thrombosis, and intrahepatic fat contents in children with uncomplicated obesity. METHODS Obese children with normal glucose tolerance but elevated highly sensitive C-reactive protein (hsCRP) and/or fibrinogen concentrations (>2 standard deviations) were randomized to structured diet… (More)

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