Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality

@article{Eurich2009MetforminTI,
  title={Metformin treatment in diabetes and heart failure: when academic equipoise meets clinical reality},
  author={D T Eurich and Ross T. Tsuyuki and Sumit Ranjan Majumdar and Finlay Aleck McAlister and Richard Lewanczuk and Marcelo C. Shibata and Jeffrey A. Johnson},
  journal={Trials},
  year={2009},
  volume={10},
  pages={12 - 12}
}
OBJECTIVE Metformin has had a 'black box' contraindication in diabetic patients with heart failure (HF), but many believe it to be the treatment of choice in this setting. Therefore, we attempted to conduct a pilot study to evaluate the feasibility of undertaking a large randomized controlled trial with clinical endpoints. STUDY DESIGN The pilot study was a randomized double blinded placebo controlled trial. Patients with HF and type 2 diabetes were screened in hospitals and HF clinics in… CONTINUE READING