Metformin therapy in patients with chronic kidney disease.

@article{Duong2012MetforminTI,
  title={Metformin therapy in patients with chronic kidney disease.},
  author={Janna K Duong and Darren M Roberts and Timothy J. Furlong and Shaun S Kumar and Jerry R Greenfield and Carl M. J. Kirkpatrick and Garry G Graham and Katrina M. Williams and Richard O. Day},
  journal={Diabetes, obesity & metabolism},
  year={2012},
  volume={14 10},
  pages={
          963-5
        }
}
Metformin therapy is limited in patients with chronic kidney disease (CKD) due to the potential risk of lactic acidosis. This open-label observational study investigated metformin and lactate concentrations in patients with CKD (n = 22; creatinine clearances 15-40 ml/min) and in two dialysed patients. Patients were prescribed a range of metformin doses (250-2000 mg daily) and metformin concentrations were compared with data from healthy subjects (scaled to 1500 mg twice daily). A subset of… CONTINUE READING

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