Metformin therapy in diabetes: the role of cardioprotection.

@article{Messaoudi2013MetforminTI,
  title={Metformin therapy in diabetes: the role of cardioprotection.},
  author={Saloua el Messaoudi and Gerard A P J M Rongen and Niels P. Riksen},
  journal={Current atherosclerosis reports},
  year={2013},
  volume={15 4},
  pages={314}
}
In patients with diabetes mellitus, the incidence of cardiovascular disease is increased, and the outcome following cardiovascular events is worse. The antihyperglycemic drug metformin appears to limit cardiovascular death in patients with type 2 diabetes. Indeed, preclinical studies have demonstrated that metformin limits (myocardial) ischemia and reperfusion injury, independent from its glucose-lowering effect. This cardioprotection is mediated by activation of the Reperfusion Injury Salvage… CONTINUE READING

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