Metformin therapy in diabetes: the role of cardioprotection.

  title={Metformin therapy in diabetes: the role of cardioprotection.},
  author={Saloua el Messaoudi and Gerard A P J M Rongen and Niels P. Riksen},
  journal={Current atherosclerosis reports},
  volume={15 4},
In patients with diabetes mellitus, the incidence of cardiovascular disease is increased, and the outcome following cardiovascular events is worse. The antihyperglycemic drug metformin appears to limit cardiovascular death in patients with type 2 diabetes. Indeed, preclinical studies have demonstrated that metformin limits (myocardial) ischemia and reperfusion injury, independent from its glucose-lowering effect. This cardioprotection is mediated by activation of the Reperfusion Injury Salvage… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 20 extracted citations

Use of non-insulin therapies for type 1 diabetes.

Diabetes technology & therapeutics • 2013
View 10 Excerpts
Highly Influenced

Metformin: Non-glycemic Effects and Potential Novel Indications.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists • 2016
View 1 Excerpt

Similar Papers

Loading similar papers…