Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.

@article{MorinPapunen1998MetforminTI,
  title={Metformin therapy improves the menstrual pattern with minimal endocrine and metabolic effects in women with polycystic ovary syndrome.},
  author={Laure C Morin-Papunen and R M Koivunen and Aimo O Ruokonen and Hannu K Martikainen},
  journal={Fertility and sterility},
  year={1998},
  volume={69 4},
  pages={691-6}
}
OBJECTIVE To determine the clinical, hormonal, and biochemical effects of 4-6 months of metformin therapy in obese patients with polycystic ovary syndrome (PCOS). DESIGN Prospective study. SETTING The Gynecological Endocrine Unit of University Central Hospital, Oulu, Finland. PATIENT(S) Twenty obese patients with PCOS. INTERVENTION(S) Patients were treated with 0.5 g of metformin three times daily for 4-6 months. MAIN OUTCOME MEASURE(S) Clinical symptoms, menstrual pattern, and… CONTINUE READING

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