Metformin therapy and diabetes in pregnancy

@article{Simmons2004MetforminTA,
  title={Metformin therapy and diabetes in pregnancy},
  author={David Simmons and Barry N J Walters and Janet A. Rowan and Harold D. McIntyre},
  journal={Medical Journal of Australia},
  year={2004},
  volume={180}
}
No adverse pregnancy outcomes with metformin use have been reported, except in one unmatched study. Otherwise, the studies are small and non‐randomised, with the exception of one prospective, randomised controlled trial, currently under way, comparing metformin with insulin in women with gestational diabetes mellitus (the MiG trial). No long‐term follow‐up data for offspring of mothers receiving metformin have been published. Any woman with diabetes should be as close to euglycaemia as possible… Expand
Metformin treatment for Type 2 diabetes in pregnancy?
  • D. Simmons
  • Medicine
  • Best practice & research. Clinical endocrinology & metabolism
  • 2010
TLDR
There is sufficient evidence that metformin is safe used throughout pregnancy, with no worsening of obstetric or perinatal outcomes, and women may benefit from the lesser weight gain. Expand
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TLDR
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TLDR
Preliminary data suggest that metformin for this population may be both safe and effective, and large blinded, randomized clinical trials are underway to confirm the preliminary safety data. Expand
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TLDR
Not only the clinical and experimental evidence that supports the benefits of using metformin during pregnancy but also the evidence showing a possible negative impact of this drug on the offspring's development are discussed. Expand
Real‐world experience of metformin use in pregnancy: Observational data from the Northern Territory Diabetes in Pregnancy Clinical Register
TLDR
In Australia's Northern Territory, Indigenous mothers account for 33% of births and have high rates of hyperglycemia in pregnancy, and the use of metformin is common. Expand
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TLDR
Metformin therapy resulted in optimum control of blood sugar in most of the women with GDM without any significant side-effects in the mother or in the fetus-neonate. Expand
[Polycystic ovary syndrome and pregnancy: clinical experience].
TLDR
PCOS mothers showed a higher prevalence of gestational diabetes and SGA newborns, and seems to be more related to the BMI at the initiation of pregnancy, and to the PCOS condition of the mother. Expand
Improving outcomes of pregnancy for women with type 1 and type 2 diabetes
TLDR
Greater awareness regarding the risks among women with diabetes as well as primary and secondary healthcare professionals is required, if pregnancy outcomes are to be improved. Expand
Metformin in the treatment of polycystic ovary syndrome.
  • D. Motta
  • Medicine
  • Current pharmaceutical design
  • 2008
TLDR
The present review explores some of the actions and efficacy of metformin in the treatment of PCOS during different reproductive periods. Expand
Exercise for pregnant women for preventing gestational diabetes mellitus.
TLDR
Evidence from one single large trial suggested no significant difference in the incidence of developing pregnancy hyperglycaemia not meeting GDM diagnostic criteria, pre-eclampsia or admission to neonatal ward between the two study groups. Expand
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References

SHOWING 1-10 OF 27 REFERENCES
Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome.
TLDR
In PCOS, use of metformin is associated with a 10-fold reduction in gestational diabetes (31% to 3%). Expand
Metformin in management of pregnant insulin-independent diabetics
TLDR
Pregnant “maturity-onset” (insulin-independent), established and gestational, diabetics were treated with Metformin in the second and third trimester after dietary treatment had failed, with a high incidence of neonatal jaundice requiring phototherapy and low infant morbidity. Expand
Effects of metformin on early pregnancy loss in the polycystic ovary syndrome.
TLDR
Metformin administration during pregnancy reduces first-trimester pregnancy loss in women with the polycystic ovary syndrome. Expand
Pregnancy outcomes among women with polycystic ovary syndrome treated with metformin.
TLDR
Metformin therapy during pregnancy in women with PCOS was safely associated with reduction in SAB and in GD, was not teratogenic, and did not adversely affect birthweight or height, or height and weight, weight, and motor and social development at 3 and 6 months of life. Expand
The management of non-insulin-dependent diabetes during pregnancy.
TLDR
It is suggested that the regimen outlined here is acceptable to the patients, is safe, gives excellent results and furthermore teaches the diabetic mother proper dietary control and combats lifelong obesity. Expand
Continuing metformin throughout pregnancy in women with polycystic ovary syndrome appears to safely reduce first-trimester spontaneous abortion: a pilot study.
TLDR
Metformin therapy throughout pregnancy in women with PCOS reduces the otherwise high rate of first-trimester spontaneous abortion seen among women not receiving metformin and does not appear to be teratogenic. Expand
The Australasian Diabetes in Pregnancy Society consensus guidelines for the management of type 1 and type 2 diabetes in relation to pregnancy
TLDR
Strict control of blood glucose levels should be pursued before conception and maintained throughout the pregnancy (glycohaemoglobin level as close as possible to the reference range) and management should be by a multidisciplinary team experienced in the management of diabetes in pregnancy. Expand
Pregnancy in established non-insulin-dependent diabetics. A five-and-a-half year study at Groote Schuur Hospital.
  • E. Coetzee, W. Jackson
  • Medicine
  • South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
  • 1980
TLDR
Pregnant women with established insulin-independent diabetes appear to be safe drugs during pregnancy when properly used, and neonatal hypoglycaemia may be abolished if patients receiving tablets or insulin are given continuous, intravenous low-dose insulin 24 hours before planned delivery. Expand
Type 2 diabetes in pregnancy: a growing concern
TLDR
There is evidence that rising rates of type 2 diabetes in pregnancy could lead to increasing number of complications in pregnancy for both mothers and fetuses. Expand
Pre-Conception Care of Diabetes, Congenital Malformations, and Spontaneous Abortions
TLDR
The purpose of this technical review is to provide the detailed background to the American Diabetes Association's Position Statement on clinical guidelines for pre-conception care of women with diabetes. Expand
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