Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.

@article{Caton2010MetforminSH,
  title={Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.},
  author={Paul Caton and Nanda K Nayuni and Julius E Kieswich and Noorafza Q. Khan and Muhammed M. Yaqoob and Roger Corder},
  journal={The Journal of endocrinology},
  year={2010},
  volume={205 1},
  pages={
          97-106
        }
}
Abnormal elevation of hepatic gluconeogenesis is central to the onset of hyperglycaemia in patients with type 2 diabetes mellitus (T2DM). Metformin corrects hyperglycaemia through inhibition of gluconeogenesis, but its mechanism of action is yet to be fully described. SIRT1 and GCN5 (listed as KAT2A in the MGI Database) have recently been identified as regulators of gluconeogenic gene expression through modulation of levels and activity of the coactivators cAMP-response element binding protein… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 100 CITATIONS, ESTIMATED 64% COVERAGE

Leucine amplifies the effects of metformin on insulin sensitivity and glycemic control in diet-induced obese mice.

  • Metabolism: clinical and experimental
  • 2015
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2014
VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 12 Highly Influenced Citations

  • Averaged 8 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carlos Lerin, +3 authors Pere Puigserver
  • Nature
  • 2005
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL