Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

@inproceedings{Chen2016MetforminSA,
  title={Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms},
  author={Suet Ching Chen and Rebecca A Brooks and Jessica Anne Houskeeper and Shaun K. Bremner and Julia A. Dunlop and Benoit Viollet and Pamela Jane Logan and Ian P Salt and S Faisal Ahmed and Stephen J Yarwood},
  booktitle={Molecular and Cellular Endocrinology},
  year={2016}
}
People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell development (adipogenesis). The commonly used anti-diabetic drug, metformin, activates the osteogenic transcription factor Runt-related transcription factor 2 (Runx2), which may suppress… CONTINUE READING
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