Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states.

@article{Kang2016MetforminSI,
  title={Metformin stimulates IGFBP-2 gene expression through PPARalpha in diabetic states.},
  author={Hye Suk Kang and Ho Chan Cho and Jae-ho Lee and Goo Taeg Oh and Seung-Hoi Koo and Byung-Hyun Park and In-kyu Lee and Hueng-Sik Choi and Dae-Kyu Song and Seung Soon Im},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={23665}
}
The anti-diabetic drug, metformin, exerts its action through AMP-activated protein kinase (AMPK), and Sirtuin (Sirt1) signaling. Insulin-like growth factor (IGF)-binding protein 2 (IGFBP-2) prevents IGF-1 binding to its receptors, thereby contributing to modulate insulin sensitivity. In this study, we demonstrate that metformin upregulates Igfbp-2 expression through the AMPK-Sirt1-PPARα cascade pathway. In the liver of high fat diet, ob/ob, and db/db mice, Igfbp-2 expression was significantly… CONTINUE READING
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