Metformin selectively targets redox control of complex I energy transduction

@article{Cameron2018MetforminST,
  title={Metformin selectively targets redox control of complex I energy transduction},
  author={Amy R. Cameron and L. Logie and Kashyap A. Patel and Stefan Erhardt and S. Bacon and P. Middleton and J. Harthill and C. Forteath and Josh T. Coats and Calum Kerr and H. Curry and D. Stewart and K. Sakamoto and Peter Repi{\vs}{\vc}{\'a}k and M. Paterson and I. Hassinen and G. McDougall and G. Rena},
  journal={Redox Biology},
  year={2018},
  volume={14},
  pages={187 - 197}
}
Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to account for this difference. In primary hepatocytes and H4IIE hepatoma cells we found that antihyperglycaemic diguanides DG5-DG10 and the biguanide phenformin were up to 1000-fold more potent than metformin on cell signalling… Expand
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