Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.

@article{Hirsch2009MetforminST,
  title={Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission.},
  author={Heather A. Hirsch and Dimitrios C. Iliopoulos and Philip N Tsichlis and Kevin Struhl},
  journal={Cancer research},
  year={2009},
  volume={69 19},
  pages={7507-11}
}
The cancer stem cell hypothesis suggests that, unlike most cancer cells within a tumor, cancer stem cells resist chemotherapeutic drugs and can regenerate the various cell types in the tumor, thereby causing relapse of the disease. Thus, drugs that selectively target cancer stem cells offer great promise for cancer treatment, particularly in combination with chemotherapy. Here, we show that low doses of metformin, a standard drug for diabetes, inhibits cellular transformation and selectively… CONTINUE READING
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