Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells.

@article{Gao2008MetforminRO,
  title={Metformin regulates osteoblast and adipocyte differentiation of rat mesenchymal stem cells.},
  author={Ying Gao and Jing Xue and X Li and Yongqian Jia and Jing Hu},
  journal={The Journal of pharmacy and pharmacology},
  year={2008},
  volume={60 12},
  pages={1695-700}
}
Metformin is widely used for the treatment of type 2 diabetes mellitus. In this study, we evaluated the effects of metformin on the osteoblast and adipocyte differentiation of rat marrow mesenchymal stem cells (MSCs) in culture. Treatment of MSCs in osteoblastic or adipogenic medium with 100 muM metformin for 21 days led to an increased mRNA expression of the osteoblast markers but a decreased mRNA expression of the adipocyte markers in the MSCs. Metformin markedly stimulated deposition of… CONTINUE READING

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