Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.


BACKGROUND Some studies have shown that metformin activates AMP-activated protein kinase (AMPK) and has a potent cardioprotective effect against ischemia/reperfusion injury. Because AMPK also is activated in animal models of heart failure, we investigated whether metformin decreases cardiomyocyte apoptosis and attenuates the progression of heart failure in… (More)
DOI: 10.1161/CIRCULATIONAHA.108.798561


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