Metformin potentiates rapamycin and cisplatin in gastric cancer in mice

@inproceedings{Yu2015MetforminPR,
  title={Metformin potentiates rapamycin and cisplatin in gastric cancer in mice},
  author={Yu Yu and Wenzheng Fang and Tian Xia and Ying Chen and Yunshu Gao and Xiaodong Jiao and Suyun Huang and Jiejun Wang and Zhaosheng Li and Keping Xie},
  booktitle={Oncotarget},
  year={2015}
}
Here we showed that pAMPKα and PTEN were down-regulated and p-mTOR, p-S6, p-4EBP1, MMP7, and DCN1 were up-regulated in human gastric cancer tissue samples as compared to that in the noncancerous tissues. Metformin inhibited tumor growth in mice. Also it enhanced cisplatin- or rapamycin-induced reduction of tumor growth as compared with treatment of either drug alone. In addition to activation of AMPK and suppression of the mTOR pathway, a series of increased and decreased genes expression were… CONTINUE READING
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