Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs

@inproceedings{Protti2012MetforminOB,
  title={Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs},
  author={Alessandro Protti and Francesco Fortunato and Massimo Monti and Sarah Vecchio and Stefano Gatti and Giacomo Comi and Rachele De Giuseppe and Luciano Gattinoni},
  booktitle={Critical care},
  year={2012}
}
INTRODUCTION Hepatic mitochondrial dysfunction may play a critical role in the pathogenesis of metformin-induced lactic acidosis. However, patients with severe metformin intoxication may have a 30 to 60% decrease in their global oxygen consumption, as for generalized inhibition of mitochondrial respiration. We developed a pig model of severe metformin… CONTINUE READING