Metformin is synthetically lethal with glucose withdrawal in cancer cells

@inproceedings{Khurana2012MetforminIS,
  title={Metformin is synthetically lethal with glucose withdrawal in cancer cells},
  author={Ashwani Khurana and Viji Shridhar},
  booktitle={Cell cycle},
  year={2012}
}
DnA damage and genomic instability are central both to the evolution and treatment of cancer. As a result, in recent years, much interest has focused on cellular DnA damage responses and whether these can be manipulated for therapy. 1 DnA damage activates a complex, interacting web of DnA repair and cell cycle checkpoint processes that offer a diverse range of potentially druggable targets. 1 These include multiple protein kinases that signal the presence of damage, such as ATM, ATR, Chk1 and… CONTINUE READING