Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium
@article{Triggle2017MetforminIN, title={Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium}, author={Chris R. Triggle and Hong Ding}, journal={Acta Physiologica}, year={2017}, volume={219} }
Metformin, a synthetic dimethyl biguanide, has been in clinical use for over 55 years, and today is considered the first‐choice drug for the treatment of type 2 diabetes used by an estimated 125 million people worldwide. Metformin is orally effective, not metabolized, excreted unchanged by the kidney, relatively free of side effects and well tolerated by the majority of patients. Of importance is that the United Kingdom Prospective Diabetes Study 20‐year study of type 2 diabetics, completed in…
83 Citations
Metformin - a new approach.
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- 2021
The benefits of using metformin in the treatment of various diseases are presented, including diabetes, cancer, and other diseases.
Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?
- Biology, MedicineBiomedicines
- 2020
Aim of this review is to assess metformin’s beneficial effects on endothelial dysfunction in T2DM, which could preempt development of atherosclerosis.
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- Medicine, BiologyFrontiers in Pharmacology
- 2020
The role and molecular mechanisms by which metformin acts through VSMCs to protect CVD are provided, including AS, restenosis, and pulmonary hypertension.
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- Medicine, BiologyEuropean journal of pharmacology
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The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)
- MedicineCardiovascular Diabetology
- 2017
Regardless of glycemic improvement, combination therapy of vildagliptin and metformin did not affect endothelial function but may exert favorable effects on adipokine levels and lipid profile in patients with type 2 diabetes without advanced atherosclerosis.
Metformin, Macrophage Dysfunction and Atherosclerosis
- Biology, MedicineFrontiers in Immunology
- 2021
Macrophages play an important role in a variety of diseases, and improving macrophage dysfunction may be an important mechanism for metformin to expand its pleiotropic pharmacological profile.
The Effects of Pycnogenol® as Add‐on Drug to Metformin Therapy in Diabetic Rats
- Chemistry, BiologyPhytotherapy research : PTR
- 2016
Both used agents, PYC and MET, showed improvement of blood glucose levels, vascular reactivity, left ventricular hypertrophy, expression of AMPK, glucose transporter 4 (GLUT4) and calcium/calmodulin‐dependent protein kinase II (CaMKII) in left ventricle of the hearts, however, the combination of these interventions has failed to possess higher efficacy.
Impact of currently used anti-diabetic drugs on myoendothelial communication.
- Medicine, BiologyCurrent opinion in pharmacology
- 2018
Mechanisms of cardiovascular protection of non-insulin antidiabetic medications
- Medicine, BiologyDiabetes mellitus
- 2018
The pathophysiological mechanisms underlying the claimed cardiovascular protection of the different glucose-lowering drugs, the available evidence-based data for their protection, the potential adverse effects, and the different phenotypes of patients eligible for a specific treatment are highlighted.
Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing
- Biology, MedicineAgeing Research Reviews
- 2018
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