Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma.

@article{Nakayama2016MetforminIT,
  title={Metformin inhibits the radiation-induced invasive phenotype of esophageal squamous cell carcinoma.},
  author={Akira Nakayama and Itasu Ninomiya and Shinichi Harada and Tomoya Tsukada and Koichi Okamoto and Shinichi Nakanuma and Seisho Sakai and Isamu Makino and Jun Kinoshita and Hironori Hayashi and Katsunobu Oyama and Tomoharu Miyashita and Hidehiro Tajima and Hiroyuki Takamura and Sachio Fushida and Tetsuo Ohta},
  journal={International journal of oncology},
  year={2016},
  volume={49 5},
  pages={1890-1898}
}
Esophageal cancer is one of the most aggressive tumor types because of its invasiveness and metastatic potential. Several reports have described an association between increased invasiveness after ionizing radiation (IR) treatment and epithelial-to-mesenchymal transition (EMT). The biguanide metformin is reported to prevent transforming growth factor-β (TGF-β)-induced EMT and proliferation of cancer. This study examined whether IR induces EMT and promotes the invasive potential of TE-9… CONTINUE READING
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