Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

@inproceedings{Wheaton2014MetforminIM,
  title={Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis},
  author={William W. Wheaton and Samuel E. Weinberg and Robert B Hamanaka and Saul Soberanes and Lucas B Sullivan and Elena Ans{\'o} and Andrea Glasauer and Eric Dufour and Gokhan M Mutlu and GR Scott Budigner and Navdeep S Chandel},
  booktitle={eLife},
  year={2014}
}
Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metformin inhibits mitochondrial complex I (NADH dehydrogenase) activity and cellular respiration. Metformin inhibited cellular proliferation in the presence of glucose, but induced cell death upon glucose deprivation, indicating that cancer cells rely… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 52 references

Clinical pharmacokinetics of metformin.

Clinical pharmacokinetics • 2011
View 3 Excerpts
Highly Influenced

Metformin prevents tobacco carcinogen--induced lung tumorigenesis.

Cancer prevention research • 2010
View 3 Excerpts
Highly Influenced

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

VM Gohil, SA Sheth, +8 authors VK. Mootha
Nature Biotechnology 28:249–255. doi: 10.1038/nbt.1606. • 2010
View 2 Excerpts
Highly Influenced

on reductive glutamine metabolism

M Foretz, S Hebrard, +6 authors B Viollet
Cancer Research • 2010
View 2 Excerpts
Highly Influenced

Dose translation from animal to human studies revisited.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2008
View 2 Excerpts
Highly Influenced

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