Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells.

  title={Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells.},
  author={Feng-Qiang Yang and J Z Wang and Jia-Sheng Yan and Jian-hua Huang and Wei Hua Li and Jian-ping Che and Guang-chun Wang and Min Liu and Jun-hua Zheng},
  journal={International journal of clinical and experimental medicine},
  volume={7 10},
Accumulating evidence suggests that metformin, a biguanide class of anti-diabetic drugs, possesses anti-cancer properties and may reduce cancer risk and improve prognosis. However, the mechanism by which metformin affects various cancers, including renal cancer still unknown. MiR-26a induces cell growth, cell cycle and cell apoptosis progression via direct targeting of Bcl-2, clyclin D1 and PTEN in cancer cells. In the present study, we used 786-O human renal cancer cell lines to study the… CONTINUE READING
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croRNA - 26 a suppresses tumor growth and metastasis of human hepatocellular carcinoma by targeting interleukin - 6 - Stat 3 pathway

  • C Oliveras-Ferraros, S Cufí, +4 authors JA Menendez
  • Hepatology
  • 2013

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