Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation

@article{Kim2011MetforminIP,
  title={Metformin inhibits P‐glycoprotein expression via the NF‐$\kappa$B pathway and CRE transcriptional activity through AMPK activation},
  author={Hyung Gyun Kim and Tran Thi Hien and Eun Hee Han and Yong Pil Hwang and Jae Ho Choi and Keon Wook Kang and Kwang‐il Kwon and Bong-Hee Kim and Sang Kyum Kim and Gye Yong Song and Tae Cheon Jeong and Hye Gwang Jeong},
  journal={British Journal of Pharmacology},
  year={2011},
  volume={162}
}
BACKGROUND AND PURPOSE The expression of P‐glycoprotein (P‐gp), encoded by the multidrug resistance 1 (MDR1) gene, is associated with the emergence of the MDR phenotype in cancer cells. We investigated whether metformin (1,1‐dimethylbiguanide hydrochloride) down‐regulates MDR1 expression in MCF‐7/adriamycin (MCF‐7/adr) cells. 
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Highly Influential Citations
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Background Citations
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160 Citations

JNK‐AKT‐NF‐&kgr;B controls P‐glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells

Reversal of multidrug resistance of hepatocellular carcinoma cells by metformin through inhibiting NF-κB gene transcription.

The synergistic effect of metformin and NF-κB siRNA were found in HepG2/ADM cells with regard to proliferation inhibition, cell cycle arrest and inducing cell apoptosis.

Metformin suppresses the proliferation and invasion through NF-kB and MMPs in MCF-7 cell line

Metformin may act on the proliferation, and the processes of invasion and metastasis of MCF-7 cells through blocking NF-kB, which is intensely expressed in breast cancer cells, and through diminishing the expression of M MP-2 and MMP-9 significantly.

Repression of integrin-linked kinase by antidiabetes drugs through cross-talk of PPARγ- and AMPKα-dependent signaling: role of AP-2α and Sp1.

Nuclear Transcription Factor Kappa B Downregulation Reduces Chemoresistance in Bone Marrow-derived Cells Through P-glycoprotein Modulation.

Mechanism of P-glycoprotein expression in the SGC7901 human gastric adenocarcinoma cell line induced by cyclooxygenase-2.

  • K. GuYu Chen
  • Biology, Medicine
    Asian Pacific journal of cancer prevention : APJCP
  • 2012
COX-2 may induce the expression of P-gp in SGC7901 cell line via the NF-kappa B pathway with pacliaxel stimulation with dose- dependence.

Reversal of P-glycoprotein-mediated multidrug resistance is induced by mollugin in MCF-7/adriamycin cells.

Metformin increases the cytotoxicity of oxaliplatin in human DLD‐1 colorectal cancer cells through down‐regulating HMGB1 expression

Treatment with OXA and metformin resulted in cytotoxicity and cell growth inhibition synergistically, accompanied with reduced HMGB1 level, which may have implications for the rational design of future drug regimens incorporating OxA and meetformin for the treatment of CRC.

NF-κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells

Modulate P-gp activity in colon cancer cells using NF-κB decoy oligodeoxynucleotides (ODNs) that are effectively delivered into the nucleus of colorectal cancer cells by self-assembling nonviral nanoparticles comprising the novel poly(N,N-dimethylaminoethylmethacrylate) diblock copolymer (pHPMA-b-pDMAEMA).

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells.

This study demonstrated metformin inhibited by cell proliferation, cell migration ability, clonogenic ability, and cancer stem cell population, and suggested novel anticancer mechanism of met formin that inhibited DNA replication machinery, such as the MCM family in SNU-C5_5FuR.
...

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