Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation

@article{Kim2011MetforminIP,
  title={Metformin inhibits P‐glycoprotein expression via the NF‐$\kappa$B pathway and CRE transcriptional activity through AMPK activation},
  author={Hyung Gyun Kim and T. T. Hien and E. Han and Y. Hwang and J. Choi and K. Kang and K. Kwon and Bong-Hee Kim and S. K. Kim and G. Y. Song and T. Jeong and H. Jeong},
  journal={British Journal of Pharmacology},
  year={2011},
  volume={162}
}
BACKGROUND AND PURPOSE The expression of P‐glycoprotein (P‐gp), encoded by the multidrug resistance 1 (MDR1) gene, is associated with the emergence of the MDR phenotype in cancer cells. We investigated whether metformin (1,1‐dimethylbiguanide hydrochloride) down‐regulates MDR1 expression in MCF‐7/adriamycin (MCF‐7/adr) cells. 

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