Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells

@article{Hodeib2018MetforminID,
  title={Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells},
  author={M. Hodeib and Martin P. Ogrodzinski and L. Vergnes and K. Reue and B. Karlan and S. Lunt and P. Aspuria},
  journal={Oncotarget},
  year={2018},
  volume={9},
  pages={4044 - 4060}
}
Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC). Studies describing the mechanisms by which metformin affects HGSC are ongoing, but detailed analysis of its effect on the cellular metabolism of both HGSC cells and their precursor, normal fallopian tube secretory epithelial cells (FTSECs), is lacking. We addressed the effects of… Expand
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References

SHOWING 1-10 OF 30 REFERENCES
Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Metformin directly acts on mitochondria to alter cellular bioenergetics
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
Metformin targets ovarian cancer stem cells in vitro and in vivo.
Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer
Metformin—mode of action and clinical implications for diabetes and cancer
...
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2
3
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