Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

Abstract

Although the antitumor role of metformin has been widely reported, the molecular mechanism of this biguanide agent in the inhibition of tumor progression remains unclear. Here, we identified miR-708-5p as a novel target of metformin in prostate cancer cells. Metformin promotes increased expression of miR-708-5p, leading to suppression of endoplasmic… (More)
DOI: 10.1038/oncsis.2015.18

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