Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo.

@article{Suwa2006MetforminIT,
  title={Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo.},
  author={Masataka Suwa and Toru Egashira and Hiroshi Nakano and Haruka Sasaki and Shuzo Kumagai},
  journal={Journal of applied physiology},
  year={2006},
  volume={101 6},
  pages={
          1685-92
        }
}
AMP-activated protein kinase (AMPK), which was activated by an antihyperglycemic drug metformin, has been hypothesized to mediate metabolic adaptations. The purposes of the present study were 1) to confirm whether acute metformin administration induced AMPK phosphorylation and 2) to determine whether chronic metformin treatment increased the peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) protein expression, glycolytic and oxidative enzyme activities, and… 

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