Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

@article{Musi2002MetforminIA,
  title={Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.},
  author={Nicolas Musi and Michael F. Hirshman and Jonas Nygren and Monika Svanfeldt and Peter N B{\aa}venholm and Olav Rooyackers and Gaochao Zhou and Joanne M. Williamson and Olle Ljunqvist and Suad Efend{\'i}c and David Moller and Anders Thorell and Laurie J Goodyear},
  journal={Diabetes},
  year={2002},
  volume={51 7},
  pages={2074-81}
}
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle; however, the molecular site of metformin action is not well understood. AMP-activated protein kinase (AMPK) activity increases in response to depletion of cellular energy stores, and this enzyme has been implicated in the stimulation of glucose uptake into skeletal muscle and the inhibition of liver gluconeogenesis. We… CONTINUE READING
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In the present study , we evaluated whether therapeutic doses of metformin increase AMPK activity in vivo in subjects with type 2 diabetes .
Metformin increases AMP - activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes .
These findings suggest that the metabolic effects of metformin in subjects with type 2 diabetes may be mediated by the activation of AMPK alpha2 .
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle ; however , the molecular site of metformin action is not well understood .
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle ; however , the molecular site of metformin action is not well understood .
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle ; however , the molecular site of metformin action is not well understood .
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle ; however , the molecular site of metformin action is not well understood .
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle ; however , the molecular site of metformin action is not well understood .
Metformin is an effective hypoglycemic drug that lowers blood glucose concentrations by decreasing hepatic glucose production and increasing glucose disposal in skeletal muscle ; however , the molecular site of metformin action is not well understood .
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